A double-blind, placebo-controlled study enrolled patients who had extended histories of receiving and tolerating BOTOX injections, with prior individualized adjustment of dose. The mean BOTOX dose administered to patients in this study was 236 Units (25th to 75th percentile range of 198 Units to 300 Units). The BOTOX dose was divided among the affected muscles [see Clinical Studies (14.7)]. Dosing in initial and sequential treatment sessions should be tailored to the individual patient based on the patient’s head and neck position, localization of pain, muscle hypertrophy, patient response, and adverse event history. The initial dose for a patient without prior use of BOTOX should be at a lower dose, with subsequent dosing adjusted based on individual response.
Spread of toxin effects (this carries a Boxed warning in the Botox Prescribing Information). In some cases, the effect of botulinum toxin A may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body
To get more personalized information, the best thing to do is to schedule a consultation with a healthcare provider.
Botox pricing is most commonly calculated per unit. The cost per unit and total treatment price can vary by location, provider expertise, and clinic reputation.
Muscle Strength and Mass: Individuals with stronger or larger facial muscles (often, but not always, correlating with male patients) will typically need more units to achieve the desired relaxation compared to those with weaker or smaller muscles.
However, there appears to be little benefit obtainable from injecting more than 5 Units per sitio. Some tolerance may be found when BOTOX is used in treating blepharospasm if treatments are given any more frequently than every three months, and is rare to have the effect be permanent.
An intravesical instillation of diluted local anesthetic with or without sedation may be used prior to injection, per local sitio practice. If a local anesthetic instillation is performed, the bladder should be drained and irrigated with sterile saline before injection.
Limitations of Use BOTOX has not been shown to improve upper extremity functional abilities, or range of motion at a joint affected by a fixed contracture. 1.5 Cervical Dystonia
Do not start any new medicines until you have told your doctor that you have received onabotulinumtoxinA in the past. Especially tell your doctor if you:
There are pelo data on the presence of Botox in human milk or adverse effects on the developing infant. Consider the benefits of Botox versus the risks, and advise against breastfeeding unless the risk is justified.
Use of BOTOX for the treatment of overactive bladder in such patients and in patients with multiple recurrent UTIs during treatment should only be considered when the benefit is likely to outweigh the potential sculptra risk. 5.13 Urinary Retention in Adults Treated for Bladder Dysfunction
Discard the vial if a vacuum does not pull the diluent into the vial. Gently mix BOTOX with the diluent by rotating the vial. Record the date and time of reconstitution on the space on the label. BOTOX should be administered within 24 hours after reconstitution. During this time period, unused reconstituted BOTOX should be stored in a refrigerator (2° to oito°C) for up to 24 hours until time of use. BOTOX vials are for single-dose only. Discard any unused portion.
Biosimilar and interchangeable products are biological products that are highly similar to and have pelo clinically meaningful differences from the reference product.
Start conservatively if you're new to Botox. It's often easier to add a little more in a follow-up appointment than to correct an overdone result (which requires waiting for the Botox to wear off naturally, usually over 3-4 months).